According to the new research conducted by scientist reveals that individual with certain abnormalities in their so-called “ATM” gene are more likely to face higher hereditary risk of pancreatic cancer.
It was reported in the issue of Cancer Discovery with the findings of stems from genetic-sequencing work conducted upon 166 pancreatic cancer patients. Even over 190 other individuals who did not have pancreatic cancer also underwent sequencing for comparative purposes.
An associate professor of oncology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins and director of the National Familial Pancreas Tumor Registry Alison Klein conducted the study.
It was found that noting than 10 percent of pancreatic cancer patients are from families in which more than one member has battled the disease. From the news releases of the American Association for Cancer Research Klein pointed out that “there was significant reason to believe this clustering was due to genetics.” Also, she further added that no previous effort had “been able to find the causative genes that explained the cluster of pancreatic cancer for a majority of these families.”
During the research, it was examined that among the pancreatic cancer patients, four were found to have the ATM gene mutation. And further according to the reports, in its contrast none of the healthy individuals who were sequenced carried the abnormality, according to the report.
It was ultimately find out that it would lead to the development of a new screening option for a disease that kills 95 percent of patients within five years of diagnosis, according to the release. Even though endoscopy is under study as another possible screening tool, there are as yet no other recommended screening alternatives for the number four cause of cancer-related death.